Normally I'm against taking things like computer games and turning them into an RPG setting, but this one is nigh-perfect.
Seriously. This game is a terrific sandbox. IMO, a minecraft-based campaign would be a lot of fun! Imagine this:
- Your character(s) find themselves in a strange land, utterly without equipment.
- The world is nigh-uninhabited and full of different climates/terrain.
- Monsters come hunting by night.
- Some monsters can destroy defenses (creepers, endermen).
- You have the skills to survive, but there is no set plan to exactly how you go about it.
- You can wander and explore
- You can build and fortify
- You can look for other people
- You can grow/raise food or hunt/gather
- Eventually, you may find natives (NPC villages), and trade with them (or raid them for food and supplies).
- There is great wealth, but it isn't lying around. You have to explore deep caverns and dig it out of the earth!
- Occasionally you encounter a treasure chest, but it's often gear and food more than magic or wealth.
- Resource management is KEY. You need food, you gear wears out, your ammo runs out, and you can only carry so much stuff.
- You can enchant items (with the proper equipment), make potions, travel to other dimensions, sail the oceans, and gather wealth.
- There are lost temples and strongholds, too.
- If you really want, you can go fight a dragon.
Granted, in a tabletop RPG you might have more than just a few of the same monsters over & over, and maybe there's a point at which you can get back to civilization with piles of gold, but the concept is basically the same.